DNA Binding Motif

Accessions: 1kb4_AB (3D-footprint 20231221)
Names: Vitamin D3 Receptor
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of VDR DNA-binding Domain Bound to a Canonical Direct Repeat with Three Base Pair Spacer (DR3) Response Element
Length: 13
Consensus: GGncAnnnrGGnC
Weblogo:
PSSM: P0 A C G T
01 0 0 96 0 G
02 0 0 96 0 G
03 24 24 24 24 n
04 16 56 8 16 c
05 72 8 8 8 A
06 24 24 24 24 n
07 24 24 24 24 n
08 24 24 24 24 n
09 24 8 56 8 r
10 0 0 96 0 G
11 0 0 96 0 G
12 24 24 24 24 n
13 0 96 0 0 C
Type: Heterodimer
Binding TFs: 1kb4_A (Zinc finger, C4 type (two domains))
1kb4_B (Zinc finger, C4 type (two domains))
Binding Sites: 1kb4_C
1kb4_D
Publications: Shaffer P.L, Gewirth D.T. Structural basis of VDR-DNA interactions on direct repeat response elements. The EMBO journal 21:2242-52 (2002). [Pubmed]

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