DNA Binding Motif

Accessions: 2ypb_AB (3D-footprint 20231221)
Names: T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Structure of the SCL:E47 complex bound to DNA
Length: 9
Consensus: GnaCAnaTG
Weblogo:
PSSM: P0 A C G T
01 0 0 96 0 G
02 24 24 24 24 n
03 54 16 13 13 a
04 0 96 0 0 C
05 96 0 0 0 A
06 24 24 24 24 n
07 57 13 13 13 a
08 0 0 0 96 T
09 0 0 96 0 G
Type: Heterodimer
Binding TFs: 2ypb_A (Helix-loop-helix DNA-binding domain)
2ypb_B (Helix-loop-helix DNA-binding domain)
Binding Sites: 2ypb_E
2ypb_F
Publications: El Omari K, Hoosdally S.J, Tuladhar K, Karia D, Hall-Ponselé E, Platonova O, Vyas P, Patient R, Porcher C, Mancini E.J. Structural basis for LMO2-driven recruitment of the SCL:E47bHLH heterodimer to hematopoietic-specific transcriptional targets. Cell reports 4:135-47 (2013). [Pubmed]

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