DNA Binding Motif

Accessions: 2as5_FN (3D-footprint 20231221)
Names: Forkhead box protein P2
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Structure of the DNA binding domains of NFAT and FOXP2 bound specifically to DNA.
Length: 13
Consensus: GGArnannTGnTT
Weblogo:
PSSM: P0 A C G T
01 0 0 96 0 G
02 0 0 96 0 G
03 96 0 0 0 A
04 51 7 29 9 r
05 24 24 24 24 n
06 59 7 16 14 a
07 24 24 24 24 n
08 24 24 24 24 n
09 0 0 0 96 T
10 0 0 96 0 G
11 24 24 24 24 n
12 0 0 0 96 T
13 7 9 14 66 T
Type: Heterodimer
Binding TFs: 2as5_F (Fork head domain)
2as5_N (Rel homology domain (RHD), IPT/TIG domain)
Binding Sites: 2as5_B
2as5_A
Publications: Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan A.D, Stroud J.C, Bates D.L, Guo L, Han A, Ziegler S.F, Mathis D, Benoist C, Chen L, Rao A. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126:375-87 (2006). [Pubmed]

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