DNA Binding Motif

Accessions: 5yej_BC (3D-footprint 20231221)
Names: TetR family transcriptional regulator
Organisms: Mycobacterium smegmatis, Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of BioQ with its naturel double-stranded DNA operator
Length: 17
Consensus: CTTGAACGnTGTTCnnG
Weblogo:
PSSM: P0 A C G T
01 0 96 0 0 C
02 11 9 4 72 T
03 7 4 4 81 T
04 0 4 86 6 G
05 81 4 4 7 A
06 96 0 0 0 A
07 0 96 0 0 C
08 0 0 96 0 G
09 24 24 24 24 n
10 0 0 0 96 T
11 0 0 96 0 G
12 0 0 0 96 T
13 7 4 4 81 T
14 9 76 9 2 C
15 24 24 24 24 n
16 24 24 24 24 n
17 0 0 96 0 G
Type: Heterodimer
Binding TFs: 5yej_B (Bacterial regulatory proteins, tetR family, Tetracyclin repressor, C-terminal all-alpha domain)
5yej_C (Bacterial regulatory proteins, tetR family, Tetracyclin repressor, C-terminal all-alpha domain)
Binding Sites: 5yej_D
5yej_F
Publications: Yan L, Tang Q, Guan Z, Pei K, Zou T, He J. Structural insights into operator recognition by BioQ in the Mycobacterium smegmatis biotin synthesis pathway. Biochim Biophys Acta Gen Subj 1862:1843-1851 (2018). [Pubmed]

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