DNA Binding Motif

						

			
Accessions: NFKB1_DBD (HumanTF 1.0), MA0105.4 (JASPAR 2024)

			
Names: NFKB1
Organisms: Homo sapiens, Oryctolagus cuniculus, Rattus norvegicus
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 3, HT-SELEX
Length: 13
Consensus: AGGGGAwTCCCCt
Weblogo: 
PSSM: P0      A      C      G      T
01   8441   2013    990    818      A
02      9      0  19047      5      G
03      0      3  19177      2      G
04      4      0  19167    318      G
05    229      3  19458     27      G
06  12004     62    821     27      A
07   7003     18     32   6744      w
08     22   1311    116  14372      T
09     17   9574      4    130      C
10    497   9536      1      3      C
11      4   9591      1      2      C
12      6   9642      2      8      C
13   1231   1293   3348   9386      t
Type: Heterodimer
Binding TFs: P19838 (Ankyrin repeat, Death domain, Rel homology domain (RHD), Ankyrin repeats (3 copies), Ankyrin repeat, Ankyrin repeats (many copies))
NFKB1_DBD (Rel homology domain (RHD))
P19838
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Wan F, Lenardo MJ. Specification of DNA binding activity of NF-kappaB proteins. Cold Spring Harb Perspect Biol : (2009). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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