DNA Binding Motif

Accessions: 1jt0_ABCD (3D-footprint 20231221)
Names: HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION
Organisms: Staphylococcus aureus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of a cooperative QacR-DNA complex
Length: 22
Consensus: ATngACCnATCGAnnGGTcTAT
Weblogo:
PSSM: P0 A C G T
01 92 3 0 1 A
02 0 1 1 94 T
03 24 24 24 24 n
04 15 11 59 11 g
05 96 0 0 0 A
06 0 96 0 0 C
07 0 96 0 0 C
08 24 24 24 24 n
09 82 1 3 10 A
10 0 0 0 96 T
11 0 96 0 0 C
12 0 0 96 0 G
13 96 0 0 0 A
14 24 24 24 24 n
15 24 24 24 24 n
16 0 0 96 0 G
17 0 0 96 0 G
18 0 0 0 96 T
19 19 46 17 14 c
20 9 13 7 67 T
21 96 0 0 0 A
22 1 1 4 90 T
Type: Heterodimer
Binding TFs: 1jt0_A / 1jt0_B / 1jt0_C (Bacterial regulatory proteins, tetR family, QacR-like protein, C-terminal region)
1jt0_D (Bacterial regulatory proteins, tetR family, QacR-like protein, C-terminal region)
Binding Sites: 1jt0_E / 1jt0_F
Publications: Schumacher M.A, Miller M.C, Grkovic S, Brown M.H, Skurray R.A, Brennan R.G. Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR. The EMBO journal 21:1210-8 (2002). [Pubmed]

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