DNA Binding Motif

Accessions: 2d45_CD (3D-footprint 20231221)
Names: Methicillin resistance regulatory protein mecI
Organisms: Staphylococcus aureus, strain N315
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of the MecI-mecA repressor-operator complex
Length: 12
Consensus: ACAnnTGTAgTA
Weblogo:
PSSM: P0 A C G T
01 96 0 0 0 A
02 5 84 7 0 C
03 96 0 0 0 A
04 24 24 24 24 n
05 24 24 24 24 n
06 5 5 5 81 T
07 5 5 79 7 G
08 0 0 0 96 T
09 96 0 0 0 A
10 11 12 62 11 g
11 11 11 5 69 T
12 96 0 0 0 A
Type: Heterodimer
Binding TFs: 2d45_C (MarR family, Penicillinase repressor)
2d45_D (MarR family, Penicillinase repressor)
Binding Sites: 2d45_G
2d45_H
Publications: Safo M.K, Ko T.P, Musayev F.N, Zhao Q, Wang A.H, Archer G.L. Structure of the MecI repressor from Staphylococcus aureus in complex with the cognate DNA operator of mec. Acta crystallographica. Section F, Structural biology and crystallization communications 62:320-4 (2006). [Pubmed]

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