DNA Binding Motif

Accessions: 1wet_A (3D-footprint 20231221)
Names: PROTEIN (PURINE REPRESSOR)
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: STRUCTURE OF THE PURR-GUANINE-PURF OPERATOR COMPLEX
Length: 8
Consensus: CGAanACg
Weblogo:
PSSM: P0 A C G T
01 0 96 0 0 C
02 0 0 96 0 G
03 96 0 0 0 A
04 54 16 13 13 a
05 24 24 24 24 n
06 96 0 0 0 A
07 0 96 0 0 C
08 16 13 54 13 g
Binding TFs: 1wet_A (Bacterial regulatory proteins, lacI family, Periplasmic binding proteins and sugar binding domain of LacI family, Periplasmic binding protein-like domain, Periplasmic binding protein domain)
Binding Sites: 1wet_B
Publications: Schumacher M.A, Glasfeld A, Zalkin H, Brennan R.G. The X-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water-mediated hydrogen bond to corepressor specificity and binding affinity. The Journal of biological chemistry 272:22648-53 (1997). [Pubmed]

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