DNA Binding Motif

						

			
Accessions: TCF3_DBD (HumanTF 1.0), MA0522.2 (JASPAR 2024)

			
Names: TCF3
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 2, HT-SELEX
Length: 10
Consensus: mrCACCTGbd
Weblogo: 
PSSM: P0      A      C      G      T
01   2823   2123   1014   1839      m
02   3423   1321   2842    213      r
03      0   7799      0      0      C
04   7799      5      0     19      A
05      0   7799   1251    317      C
06      0   7799    465      0      C
07     43     35      7   7799      T
08     27     21   7799      5      G
09    253   3014   1978   2554      b
10   2066   1393   2093   2247      d
Type: Heterodimer
Binding TFs: P15923 (Helix-loop-helix DNA-binding domain)
TCF3_DBD (Helix-loop-helix DNA-binding domain)
P15923
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Kophengnavong T, Michnowicz J.E, Blackwell T.K. Establishment of distinct MyoD, E2A, and twist DNA binding specificities by different basic region-DNA conformations. Molecular and cellular biology 20:261-72 (2000). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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