DNA Binding Motif

Accessions: MEF2D_DBD (HumanTF 1.0), MA0773.1 (JASPAR 2024)
Names: MEF2D
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 3, HT-SELEX
Length: 12
Consensus: dCTAwAAATAGm
Weblogo:
PSSM: P0 A C G T
01 2120 109 1933 1642 d
02 28 5803 0 53 C
03 3 22 0 5803 T
04 5803 8 2 6 A
05 2782 0 2 3021 w
06 5803 4 0 778 A
07 5803 0 2 217 A
08 5803 2 1 69 A
09 0 0 0 5803 T
10 5803 0 4 0 A
11 339 17 5803 5 G
12 3206 2598 70 585 m
Type: Heterodimer
Binding TFs: MEF2D_DBD (SRF-type transcription factor (DNA-binding and dimerisation domain))
Q05BX2 (SRF-type transcription factor (DNA-binding and dimerisation domain))
Q05BX2
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Wales S, Hashemi S, Blais A, McDermott JC. Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPK-MEF2 signaling. Nucleic Acids Res 42:11349-62 (2014). [Pubmed]

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