DNA Binding Motif

						

			
Accessions: E2F1_HES7_1 (HumanTF2 1.0), UN0489.1 (JASPAR 2024)

			
Names: E2F1_HES7, E2F1::HES7
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 20
Consensus: ggCACGTGcCrwtsGCGCsm
Weblogo: 
PSSM: P0      A      C      G      T
01    298    328   1101    220      g
02    271    156   1128    146      g
03     24   1399      7     25      C
04   1098     18    301     41      A
05      0   1399     38     35      C
06     33      4   1399      4      G
07      8    307      0   1092      T
08      4     94   1399     12      G
09     64    972    342    427      c
10    172    993    144     89      C
11    460    143    638    158      r
12    484     94    240    581      w
13    160    339    158    742      t
14    118    442    957     16      s
15     40     90   1399     51      G
16      0   1399     18     12      C
17     46      1   1399      0      G
18      9   1399    238     70      C
19     31    786    613    176      s
20    462    494     95    349      m
Type: Heterodimer
Binding TFs: E2F1_TF1 (E2F/DP family winged-helix DNA-binding domain)
HES7_TF2 (Helix-loop-helix DNA-binding domain)
Q9BYE0 (Helix-loop-helix DNA-binding domain)
Q9BYE0
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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