DNA Binding Motif

Accessions: 5h3r_AB (3D-footprint 2022-04-03)
Names: Multiple antibiotic resistance protein MarR
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 2022-04-03 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of mutant MarR C80S from E.coli complexed with operator DNA
Length: 18
Consensus: TnnTTGCCnGGGCAAnnT
Weblogo:
PSSM: P0 A C G T
01 4 9 4 79 T
02 24 24 24 24 n
03 24 24 24 24 n
04 4 5 4 83 T
05 4 8 5 79 T
06 0 0 96 0 G
07 0 96 0 0 C
08 4 84 4 4 C
09 24 24 24 24 n
10 1 8 79 8 G
11 0 0 96 0 G
12 0 0 96 0 G
13 0 96 0 0 C
14 84 4 4 4 A
15 96 0 0 0 A
16 24 24 24 24 n
17 24 24 24 24 n
18 5 4 4 83 T
Type: Heterodimer
Binding TFs: 5h3r_A (MarR family, MarR family, Winged helix DNA-binding domain)
5h3r_B (MarR family, MarR family, Winged helix DNA-binding domain)
Binding Sites: 5h3r_C
5h3r_D
Publications: Zhu R, Hao Z, Lou H, Song Y, Zhao J, Chen Y, Zhu J, Chen PR. Structural characterization of the DNA-binding mechanism underlying the copper(II)-sensing MarR transcriptional regulator. J Biol Inorg Chem 22:685-693 (2017). [Pubmed]

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