DNA Binding Motif

						

			
Accessions: CLOCK_FIGLA_2 (HumanTF2 1.0)

			
Names: CLOCK_FIGLA
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 24
Consensus: cCAssTGkygymmsrdrCACGTGs
Weblogo: 
PSSM: P0      A      C      G      T
01   1972   4235   2243   1197      c
02    223   9646    103     21      C
03   9646    188    567     88      A
04      8   4098   5548    481      s
05    773   4861   4786     67      s
06    195    542     63   9646      T
07    341      4   9646    976      G
08   1575   3018   4600   5046      k
09   2127   2618   2217   2684      y
10   2143   2087   3430   1986      g
11   1502   3137   2085   2922      y
12   2656   2858   1832   2300      m
13   2955   2423   2261   2007      m
14   2156   2689   2593   2208      s
15   2657   1394   3962   1634      r
16   2620   1127   2805   3094      d
17   3500   1105   4560    481      r
18    919   9646    207    299      C
19   9646    229   2770   1191      A
20      7   9646    394   2837      C
21   2848    795   9646    143      G
22   1653   2410    108   9646      T
23    332     94   9646   1475      G
24    546   4604   2587   1910      s
Type: Heterodimer
Binding TFs: CLOCK_TF1 / CLOCK_TF2 (Helix-loop-helix DNA-binding domain)
FIGLA_TF2 (Helix-loop-helix DNA-binding domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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