DNA Binding Motif

						

			
Accessions: BHLHE22_DBD (HumanTF 1.0), MA0817.1 (JASPAR 2024)

			
Names: BHLHE22, BHLHE23
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 3, HT-SELEX
Length: 12
Consensus: aAmCATATGkTw
Weblogo: 
PSSM: P0      A      C      G      T
01   2550    686    858    912      a
02   5005     55    890     44      A
03   2779   1286    932      8      m
04     21   5005      0      0      C
05   5005      0     67     17      A
06      0      4      1   5005      T
07   5005      5      3      0      A
08     47    115      5   5005      T
09      0      4   5005      7      G
10     13   1203   1771   2018      k
11    243   1468     92   5005      T
12   1523    911    964   1606      w
Type: Heterodimer
Binding TFs: BHLHE22_DBD (Helix-loop-helix DNA-binding domain)
Q8NDY6 (Helix-loop-helix DNA-binding domain)
Q8NDY6
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Atchley WR, Fitch WM. A natural classification of the basic helix-loop-helix class of transcription factors. Proc Natl Acad Sci U S A 94:5172-6 (1997). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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