DNA Binding Motif
| Accessions: | LexA (DBTBS 1.0) |
| Names: | LexA |
| Organisms: | Bacillus subtilis |
| Libraries: | DBTBS 1.0 1 1 Sierro N, Makita Y, de Hoon M, Nakai K. DBTBS: a database of transcriptional regulation in Bacillus subtilis containing upstream intergenic conservation information. Nucleic acids research 36:D93-6 (2008). [Pubmed] |
| Length: | 12 |
| Consensus: | GAACrwwyGTTC |
| Weblogo: |  |
| PSSM: | P0 A C G T 01 0.13 0 0.87 0 G 02 1 0 0 0 A 03 0.96 0.04 0 0 A 04 0 0.97 0 0.02 C 05 0.49 0 0.41 0.09 r 06 0.31 0.12 0 0.57 w 07 0.49 0 0.16 0.35 w 08 0.05 0.54 0 0.41 y 09 0.10 0 0.87 0.03 G 10 0 0 0 1 T 11 0 0 0 1 T 12 0 0.91 0 0.09 C |
| Binding TFs: | LexA (Peptidase S24-like, LexA DNA binding domain, IclR helix-turn-helix domain, Winged helix-turn-helix DNA-binding) |
| Binding Sites: | aprX_1 dinB dinC_1 dinC_2 dnaE hbs_1 lexA_1 lexA_2 lexA_3 parE pcrA recA_5 ruvA sda_1 uvrB uvrC vpr_1 xkdA ybaK_1 ydgG ydiO yhaO yhaZ yhjD yhjE ykvR yneA_1 yneA_2 yneA_3 yolC_1 yolC_2 yolD_1 yolD_2 yorB yozL_1 yozL_2 yozM_1 yozM_2 ypuD yqhB yqjW_1 yqjW_2 yqxL_1 yqzH_1 yqzH_2 |
| Publications: | Au N, Kuester-Schoeck E, Mandava V, Bothwell L.E, Canny S.P, Chachu K, Colavito S.A, Fuller S.N, Groban E.S, Hensley L.A, O'Brien T.C, Shah A, Tierney J.T, Tomm L.L, O'Gara T.M, Goranov A.I, Grossman A.D, Lovett C.M. Genetic composition of the Bacillus subtilis SOS system. Journal of bacteriology 187:7655-66 (2005). [Pubmed] Cheo D.L, Bayles K.W, Yasbin R.E. Cloning and characterization of DNA damage-inducible promoter regions from Bacillus subtilis. Journal of bacteriology 173:1696-703 (1991). [Pubmed] Lovett C.M, Cho K.C, O'Gara T.M. Purification of an SOS repressor from Bacillus subtilis. Journal of bacteriology 175:6842-9 (1993). [Pubmed] Miller M.C, Resnick J.B, Smith B.T, Lovett C.M. The bacillus subtilis dinR gene codes for the analogue of Escherichia coli LexA. Purification and characterization of the DinR protein. The Journal of biological chemistry 271:33502-8 (1996). [Pubmed] Winterling K.W, Chafin D, Hayes J.J, Sun J, Levine A.S, Yasbin R.E, Woodgate R. The Bacillus subtilis DinR binding site: redefinition of the consensus sequence. Journal of bacteriology 180:2201-11 (1998). [Pubmed] Groban E.S, Johnson M.B, Banky P, Burnett P.G, Calderon G.L, Dwyer E.C, Fuller S.N, Gebre B, King L.M, Sheren I.N, Von Mutius L.D, O'Gara T.M, Lovett C.M. Binding of the Bacillus subtilis LexA protein to the SOS operator. Nucleic acids research 33:6287-95 (2005). [Pubmed] Raymond-Denise A, Guillen N. Identification of dinR, a DNA damage-inducible regulator gene of Bacillus subtilis. Journal of bacteriology 173:7084-91 (1991). [Pubmed] Le Chatelier E, Bécherel O.J, d'Alençon E, Canceill D, Ehrlich S.D, Fuchs R.P, Jannière L. Involvement of DnaE, the second replicative DNA polymerase from Bacillus subtilis, in DNA mutagenesis. The Journal of biological chemistry 279:1757-67 (2004). [Pubmed] Haijema B.J, van Sinderen D, Winterling K, Kooistra J, Venema G, Hamoen L.W. Regulated expression of the dinR and recA genes during competence development and SOS induction in Bacillus subtilis. Molecular microbiology 22:75-85 (1996). [Pubmed] Hamoen L.W, Haijema B, Bijlsma J.J, Venema G, Lovett C.M. The Bacillus subtilis competence transcription factor, ComK, overrides LexA-imposed transcriptional inhibition without physically displacing LexA. The Journal of biological chemistry 276:42901-7 (2001). [Pubmed] Raymond-Denise A, Guillen N. Expression of the Bacillus subtilis dinR and recA genes after DNA damage and during competence. Journal of bacteriology 174:3171-6 (1992). [Pubmed] Winterling K.W, Levine A.S, Yasbin R.E, Woodgate R. Characterization of DinR, the Bacillus subtilis SOS repressor. Journal of bacteriology 179:1698-703 (1997). [Pubmed] Kawai Y, Moriya S, Ogasawara N. Identification of a protein, YneA, responsible for cell division suppression during the SOS response in Bacillus subtilis. Molecular microbiology 47:1113-22 (2003). [Pubmed] |
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