DNA Binding Motif

Accessions: 5ed4_EF (3D-footprint 20231221)
Names: Response regulator
Organisms: Mycobacterium tuberculosis, strain ATCC 25618 / H37Rv
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Structure of a PhoP-DNA complex
Length: 17
Consensus: tCnCAGnnnnnTCaCAG
Weblogo:
PSSM: P0 A C G T
01 6 10 15 65 t
02 0 90 0 6 C
03 24 24 24 24 n
04 0 96 0 0 C
05 96 0 0 0 A
06 10 0 86 0 G
07 24 24 24 24 n
08 24 24 24 24 n
09 24 24 24 24 n
10 24 24 24 24 n
11 24 24 24 24 n
12 6 10 10 70 T
13 0 91 0 5 C
14 60 10 20 6 a
15 0 96 0 0 C
16 96 0 0 0 A
17 10 5 76 5 G
Type: Heterodimer
Binding TFs: 5ed4_E (Response regulator receiver domain, Transcriptional regulatory protein, C terminal)
5ed4_F (Response regulator receiver domain, Transcriptional regulatory protein, C terminal)
Binding Sites: 5ed4_G
5ed4_H
Publications: He X, Wang L, Wang S. Structural basis of DNA sequence recognition by the response regulator PhoP in Mycobacterium tuberculosis. Sci Rep : (2016). [Pubmed]

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