DNA Binding Motif

Accessions: CUX1_HOXB13 (HumanTF2 1.0), UN0487.1 (JASPAR 2024)
Names: CUX1_HOXB13, CUX1::HOXB13
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 16
Consensus: symrTAAAhATyGATy
Weblogo:
PSSM: P0 A C G T
01 476 1688 989 107 s
02 169 1209 102 1467 y
03 1159 1518 88 605 m
04 1380 33 1296 37 r
05 0 52 35 2677 T
06 2677 36 173 550 A
07 2677 106 13 246 A
08 2677 101 85 129 A
09 771 891 145 871 h
10 2677 0 0 84 A
11 0 0 0 2677 T
12 18 1745 0 932 y
13 7 8 2677 0 G
14 2677 35 85 65 A
15 157 184 0 2677 T
16 390 1326 196 764 y
Type: Heterodimer
Binding TFs: CUX1_TF1 (Homeobox domain, CUT domain, Homeobox KN domain)
HOXB13_TF1 / HOXB13_TF2 (Homeobox domain)
Q92826 (Homeobox domain, Hox protein A13 N terminal)
HOXB13_Full (Homeobox domain, Hox protein A13 N terminal)
Q92826
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

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