DNA Binding Motif

Accessions: 5c8e_BC (3D-footprint 20231221)
Names: Light-dependent transcriptional regulator CarH
Organisms: strain HB27 / ATCC BAA-163 / DSM 7039, Thermus thermophilus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of Thermus thermophilus CarH bound to adenosylcobalamin and a 26-bp DNA segment
Length: 15
Consensus: TACAnnnnnnTGACA
Weblogo:
PSSM: P0 A C G T
01 6 6 6 78 T
02 96 0 0 0 A
03 0 96 0 0 C
04 78 6 6 6 A
05 24 24 24 24 n
06 24 24 24 24 n
07 24 24 24 24 n
08 24 24 24 24 n
09 24 24 24 24 n
10 24 24 24 24 n
11 12 6 12 66 T
12 0 0 96 0 G
13 96 0 0 0 A
14 0 72 12 12 C
15 84 0 6 6 A
Type: Heterodimer
Binding TFs: 5c8e_B (MerR family regulatory protein, B12 binding domain, MerR HTH family regulatory protein)
5c8e_C (MerR family regulatory protein, B12 binding domain, MerR HTH family regulatory protein)
Binding Sites: 5c8e_I
5c8e_J
Publications: Jost M, Fernández-Zapata J, Polanco MC, Ortiz-Guerrero JM, Chen PY, Kang G, Padmanabhan S, Elías-Arnanz M, Drennan CL. Structural basis for gene regulation by a B12-dependent photoreceptor. Nature 526:536-41 (2015). [Pubmed]

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