DNA Binding Motif

Accessions: 2hzv_ABCD (3D-footprint 2022-04-03)
Names: Nickel-responsive regulator
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 2022-04-03 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: NikR-operator DNA complex
Length: 28
Consensus: GTyTGAnnnnnnnnnnnnnnnnTCAwAC
Weblogo:
PSSM: P0 A C G T
01 0 0 96 0 G
02 0 0 0 96 T
03 8 24 8 56 y
04 0 0 0 96 T
05 0 0 96 0 G
06 96 0 0 0 A
07 24 24 24 24 n
08 24 24 24 24 n
09 24 24 24 24 n
10 24 24 24 24 n
11 24 24 24 24 n
12 24 24 24 24 n
13 24 24 24 24 n
14 24 24 24 24 n
15 24 24 24 24 n
16 24 24 24 24 n
17 24 24 24 24 n
18 24 24 24 24 n
19 24 24 24 24 n
20 24 24 24 24 n
21 24 24 24 24 n
22 24 24 24 24 n
23 0 0 0 96 T
24 0 96 0 0 C
25 80 0 16 0 A
26 48 8 16 24 w
27 96 0 0 0 A
28 0 96 0 0 C
Binding TFs: 2hzv_A / 2hzv_B / 2hzv_C / 2hzv_D (Ribbon-helix-helix protein, copG family, NikR C terminal nickel binding domain)
Binding Sites: 2hzv_I
2hzv_J
Publications: Schreiter E.R, Wang S.C, Zamble D.B, Drennan C.L. NikR-operator complex structure and the mechanism of repressor activation by metal ions. Proceedings of the National Academy of Sciences of the United States of America 103:13676-81 (2006). [Pubmed]

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