DNA Binding Motif

						

			
Accessions: RFX2_DBD_1 (HumanTF 1.0), MA0600.2 (JASPAR 2024)

			
Names: RFX2
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 3, HT-SELEX
Length: 16
Consensus: sGTTrCCATGGyAACs
Weblogo: 
PSSM: P0      A      C      G      T
01   1381   5653   4042   2336      s
02    270     12  13942      8      G
03     28     38     14  13836      T
04   1990    888     14  12503      T
05   3948    237   8026   1175      r
06     12  13197     93   1459      C
07      2  12326      5   3386      C
08   9773     38     65    184      A
09    215     88     29  13479      T
10   3132      7  12113      2      G
11   2007    128  13075      3      G
12   1359   8298    354   4297      y
13   9266     26    958   1194      A
14   9876     14     25     16      A
15      7  14067      1    309      C
16   2415   3654   5451   1441      s
Type: Heterodimer
Binding TFs: RFX2_DBD (RFX DNA-binding domain)
P48378 (RFX DNA-binding domain, RFX1 transcription activation region      )
P48378
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Emery P., Strubin M., Hofmann K., Bucher P., Mach B., Reith W. A consensus motif in the RFX DNA binding domain and binding domain mutants with altered specificity. Mol. Cell. Biol. 16:4486-4494 (1996). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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