DNA Binding Motif

						

			
Accessions: TFEB_full (HumanTF 1.0), MA0692.1 (JASPAR 2024)

			
Names: TFEB
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 2, HT-SELEX
Length: 10
Consensus: ryCACGTGAy
Weblogo: 
PSSM: P0      A      C      G      T
01   4967   1553   3748    343      r
02   2545   4936   2731   8715      y
03     17   8715      0      3      C
04   8715    286     62    274      A
05      0   8715     83   1155      C
06   2762    288   8715      5      G
07    454    169    150   8715      T
08      9     10   8715     11      G
09   8715   2342    872    807      A
10    283   5889    558   2826      y
Type: Heterodimer
Binding TFs: P19484 (Helix-loop-helix DNA-binding domain, Domain of unknown function (DUF3371))
TFEB_full (Helix-loop-helix DNA-binding domain, Domain of unknown function (DUF3371))
P19484
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Fisher D. E., Carr C. S., Parent L. A., Sharp P. A. TFEB has DNA-binding and oligomerization properties of a unique helix-loop-helix/leucine zipper family. Genes Dev. 5:2342-2352 (1991). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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