DNA Binding Motif

						

			
Accessions: MelR (RegulonDB 7.5)

			
Names: MelR, MelR DNA-binding transcriptional dual regulator
Organisms: ECK12
Libraries: RegulonDB 7.5 1
1 Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muniz-Rascado L, Garcia-Sotelo JS, Weiss V, Solano-Lira H, Martinez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernandez S, Alquicira-Hernandez K, Lopez-Fuentes A, Porron-Sotelo L, Huerta AM, Bonavides-Martinez C, Balderas-Martinez YI, Pannier L, Olvera M, Labastida A, Jimenez-Jacinto V, Vega-Alvarado L, Del Moral-Chavez V, Hernandez-Alvarez A, Morett E, Collado-Vides J. RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more. Nucleic Acids Res. 2013 Jan 1;41(D1):D203-D213. [Pubmed]
Length: 18
Consensus: cwTTmCCwkAAAmtCAGA
Weblogo: 
PSSM: P0      A      C      G      T
01      1      3      0      1      c
02      3      0      0      2      w
03      0      1      0      4      T
04      1      0      0      4      T
05      2      3      0      0      m
06      0      5      0      0      C
07      0      4      0      1      C
08      2      0      1      2      w
09      0      0      3      2      k
10      4      0      1      0      A
11      5      0      0      0      A
12      4      0      0      1      A
13      2      2      1      0      m
14      0      1      1      3      t
15      0      5      0      0      C
16      4      0      1      0      A
17      0      0      5      0      G
18      5      0      0      0      A
Binding TFs: ECK120005684 (Bacterial regulatory helix-turn-helix proteins, AraC family, Helix-turn-helix domain)
Binding Sites: ECK120012349
ECK120013194
ECK120013740
ECK120013742
ECK120016174
			
Publications: Howard VJ., Belyaeva TA., Busby SJ., Hyde EI. DNA binding of the transcription activator protein MelR from Escherichia coli and its C-terminal domain. Nucleic Acids Res. 30(12):2692-700 (2002). [Pubmed]


Wade JT., Belyaeva TA., Hyde EI., Busby SJ. Repression of the Escherichia coli melR promoter by MelR: evidence that efficient repression requires the formation of a repression loop. Mol Microbiol. 36(1):223-9 (2000). [Pubmed]


Tamai E., Belyaeva TA., Busby SJ., Tsuchiya T. Mutations that increase the activity of the promoter of the Escherichia coli melibiose operon improve the binding of MelR, a transcription activator triggered by melibiose. J Biol Chem. 275(22):17058-63 (2000). [Pubmed]


Caswell R., Webster C., Busby S. Studies on the binding of the Escherichia coli MelR transcription activator protein to operator sequences at the MelAB promoter. Biochem J. 287 ( Pt 2):501-8 (1992). [Pubmed]


Belyaeva TA., Wade JT., Webster CL., Howard VJ., Thomas MS., Hyde EI., Busby SJ. Transcription activation at the Escherichia coli melAB promoter: the role of MelR and the cyclic AMP receptor protein. Mol Microbiol. 36(1):211-22 (2000). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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