DNA Binding Motif

						

			
Accessions: 6edb_AB (3D-footprint 20231221)

			
Names: Sex-determining region Y protein,Cyclic GMP-AMP synthase
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of SRY.hcGAS-21bp dsDNA complex
Length: 14
Consensus: cATTgkknnnnnCc
Weblogo: 
PSSM: P0      A      C      G      T
01     13     56     13     14      c
02     78      6      6      6      A
03      7      7      7     75      T
04      1      2      1     92      T
05     20     20     36     20      g
06     22     22     25     27      k
07     22     22     25     27      k
08     24     24     24     24      n
09     24     24     24     24      n
10     24     24     24     24      n
11     24     24     24     24      n
12     24     24     24     24      n
13      9     69      9      9      C
14     13     56     13     14      c
Binding TFs: 6edb_B (HMG (high mobility group) box, Domain of unknown function (DUF1898))
Binding Sites: 6edb_C
6edb_D
			
Publications: Xie W, Lama L, Adura C, Tomita D, Glickman JF, Tuschl T, Patel DJ. Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. Proc Natl Acad Sci U S A 116:11946-11955 (2019). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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