DNA Binding Motif

Accessions: 2xro_ABEF (3D-footprint 20231221)
Names: HTH-TYPE TRANSCRIPTIONAL REGULATOR TTGV
Organisms: Pseudomonas putida, strain DOT-T1E
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of TtgV in complex with its DNA operator
Length: 35
Consensus: TnTCAnnnnnTGCTAnnnnnTACCGnnnnnCGAnT
Weblogo:
PSSM: P0 A C G T
01 0 0 0 96 T
02 24 24 24 24 n
03 11 8 7 70 T
04 0 96 0 0 C
05 96 0 0 0 A
06 24 24 24 24 n
07 24 24 24 24 n
08 24 24 24 24 n
09 24 24 24 24 n
10 24 24 24 24 n
11 0 0 0 96 T
12 0 0 96 0 G
13 3 87 3 3 C
14 7 7 9 73 T
15 96 0 0 0 A
16 24 24 24 24 n
17 24 24 24 24 n
18 24 24 24 24 n
19 24 24 24 24 n
20 24 24 24 24 n
21 0 0 0 96 T
22 73 9 7 7 A
23 3 87 3 3 C
24 0 96 0 0 C
25 0 0 96 0 G
26 24 24 24 24 n
27 24 24 24 24 n
28 24 24 24 24 n
29 24 24 24 24 n
30 24 24 24 24 n
31 0 96 0 0 C
32 0 0 96 0 G
33 84 6 3 3 A
34 24 24 24 24 n
35 3 3 6 84 T
Type: Heterodimer
Binding TFs: 2xro_A / 2xro_E (Bacterial transcriptional regulator, Transcriptional regulator, IclR helix-turn-helix domain, Winged helix-turn-helix DNA-binding)
2xro_B / 2xro_F (Bacterial transcriptional regulator, Transcriptional regulator, IclR helix-turn-helix domain, Winged helix-turn-helix DNA-binding)
Binding Sites: 2xro_X
2xro_Y
Publications: Lu D, Fillet S, Meng C, Alguel Y, Kloppsteck P, Bergeron J, Krell T, Gallegos M.T, Ramos J, Zhang X. Crystal structure of TtgV in complex with its DNA operator reveals a general model for cooperative DNA binding of tetrameric gene regulators. Genes & development 24:2556-65 (2010). [Pubmed]

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