DNA Binding Motif

						

			
Accessions: KLF14_DBD (HumanTF 1.0), MA0740.1 (JASPAR 2024)

			
Names: KLF14
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 3, HT-SELEX
Length: 14
Consensus: krcCACGCCCmYyt
Weblogo: 
PSSM: P0      A      C      G      T
01    430    215    966    693      k
02   1205     73   2280     71      r
03    526   1360     96    404      c
04      0   1599     10    248      C
05   1708    136     58      5      A
06      2   1596      0      2      C
07     69     36   2939     31      G
08      0   1602      3      0      C
09      0   1604      3      6      C
10      0   1609      4     65      C
11    716    961      1     31      m
12     32   1463     15    559      Y
13    280    594     89   1041      y
14    649    741    314   1670      t
Type: Heterodimer
Binding TFs: KLF14_DBD (Zinc finger, C2H2 type, BED zinc finger, Zinc-finger double domain, C2H2-type zinc finger)
Q8TD94 (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Q8TD94 (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Q8TD94
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Lomberk G, Urrutia R. The family feud: turning off Sp1 by Sp1-like KLF proteins. Biochem J : (2005). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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