DNA Binding Motif

						

			
Accessions: Tp53_DBD_3 (HumanTF 1.0), MA0106.3 (JASPAR 2024)

			
Names: Tp53
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4, HT-SELEX
Length: 18
Consensus: rACATGyCcgGrCATGTy
Weblogo: 
PSSM: P0      A      C      G      T
01   7544   1037   6563   2268      r
02  10514    116   2433    735      A
03     45  19689     13    837      C
04  11931    204    653    739      A
05   1710    374    137  18893      T
06      8      2  20393      0      G
07    244  12014    109   7106      y
08   1228  17286    417   2642      C
09   1145  11875   2151   3774      c
10   3851   1474   9954   2118      g
11   3584    756  17846   1546      G
12   7104     26   8821    190      r
13      0  19350      4      1      C
14  12925    250    157   1155      A
15   1825    118     89  17864      T
16    327     33  20549     68      G
17    879   3338    116  17859      T
18   1472   9183    825   9120      y
Type: Heterodimer
Binding TFs: P04637 (P53 DNA-binding domain, P53 tetramerisation motif, P53 transactivation motif)
P04637
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Funk W. D., Pak D. T., Karas R. H., Wright W. E., Shay J. W. A transcriptionally active DNA-binding site for human p53 protein complexes. Mol. Cell. Biol. 12:2866-2871 (1992). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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