DNA Binding Motif

Accessions: 6vvs_FT (3D-footprint 20231221)
Names: RNA polymerase sigma factor SigA
Organisms: Mycobacterium smegmatis, Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with antibiotic Sorangicin
Length: 25
Consensus: AGCAnAnnnnnnnncnnnTGTCaAG
Weblogo:
PSSM: P0 A C G T
01 96 0 0 0 A
02 0 0 96 0 G
03 0 96 0 0 C
04 96 0 0 0 A
05 24 24 24 24 n
06 78 6 6 6 A
07 24 24 24 24 n
08 24 24 24 24 n
09 24 24 24 24 n
10 24 24 24 24 n
11 24 24 24 24 n
12 24 24 24 24 n
13 24 24 24 24 n
14 24 24 24 24 n
15 12 60 12 12 c
16 24 24 24 24 n
17 24 24 24 24 n
18 24 24 24 24 n
19 12 6 6 72 T
20 0 0 96 0 G
21 0 0 0 96 T
22 0 96 0 0 C
23 60 12 12 12 a
24 96 0 0 0 A
25 0 0 96 0 G
Binding TFs: 6vvs_F (Sigma-70 factor, region 1.2, Sigma-70 region 3, Sigma-70 region 2 , Sigma-70, region 4)
Binding Sites: 6vvs_O
6vvs_P
Publications: Lilic M, Chen J, Boyaci H, Braffman N, Hubin EA, Herrmann J, Müller R, Mooney R, Landick R, Darst SA, Campbell EA. The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc Natl Acad Sci U S A 117:30423-30432 (2020). [Pubmed]

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