DNA Binding Motif

Accessions: 6b0o_A (3D-footprint 2022-04-03)
Names: Wilms tumor protein
Organisms: Homo sapiens
Libraries: 3D-footprint 2022-04-03 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Zinc finger Domain of WT1(-KTS form) with 12+1mer Oligonucleotide with 3' Triplet TGT
Length: 12
Consensus: GCGTGGGAGTGt
Weblogo:
PSSM: P0 A C G T
01 0 19 77 0 G
02 0 96 0 0 C
03 0 0 96 0 G
04 0 0 0 96 T
05 0 0 96 0 G
06 0 0 96 0 G
07 0 0 96 0 G
08 96 0 0 0 A
09 0 0 96 0 G
10 0 0 0 96 T
11 0 0 96 0 G
12 19 20 19 38 t
Binding TFs: 6b0o_A (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Binding Sites: 6b0o_B
6b0o_C
Publications: Wang D, Horton JR, Zheng Y, Blumenthal RM, Zhang X, Cheng X. Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites. Nucleic Acids Res 46:3864-3877 (2018). [Pubmed]

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