DNA Binding Motif

Accessions: 6b0o_A (3D-footprint 20231221)
Names: Wilms tumor protein
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Zinc finger Domain of WT1(-KTS form) with 12+1mer Oligonucleotide with 3' Triplet TGT
Length: 12
Consensus: GCGTGGGAGTGt
Weblogo:
PSSM: P0 A C G T
01 0 19 77 0 G
02 0 96 0 0 C
03 0 0 96 0 G
04 0 0 0 96 T
05 0 0 96 0 G
06 0 0 96 0 G
07 0 0 96 0 G
08 96 0 0 0 A
09 0 0 96 0 G
10 0 0 0 96 T
11 0 0 96 0 G
12 19 20 19 38 t
Binding TFs: 6b0o_A (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Binding Sites: 6b0o_B
6b0o_C
Publications: Wang D, Horton JR, Zheng Y, Blumenthal RM, Zhang X, Cheng X. Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites. Nucleic Acids Res 46:3864-3877 (2018). [Pubmed]

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.