DNA Binding Motif

Accessions: 6xwg_CD (3D-footprint 20231221)
Names: Retinoic acid receptor RXR-alpha
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of the Human RXR/RAR DNA-Binding Domain Heterodimer Bound to the Human RARb2 DR5 Response Element
Length: 16
Consensus: GTTCAnnnnnaGTTcA
Weblogo:
PSSM: P0 A C G T
01 6 6 78 6 G
02 0 0 0 96 T
03 0 0 0 96 T
04 0 96 0 0 C
05 96 0 0 0 A
06 24 24 24 24 n
07 24 24 24 24 n
08 24 24 24 24 n
09 24 24 24 24 n
10 24 24 24 24 n
11 64 14 12 6 a
12 0 0 96 0 G
13 0 0 0 96 T
14 6 8 6 76 T
15 12 57 15 12 c
16 96 0 0 0 A
Type: Heterodimer
Binding TFs: 6xwg_C (Zinc finger, C4 type (two domains))
6xwg_D (Zinc finger, C4 type (two domains))
Binding Sites: 6xwg_A
6xwg_B
Publications: Osz J, McEwen AG, Bourguet M, Przybilla F, Peluso-Iltis C, Poussin-Courmontagne P, Mély Y, Cianférani S, Jeffries CM, Svergun DI, Rochel N. Structural basis for DNA recognition and allosteric control of the retinoic acid receptors RAR-RXR. Nucleic Acids Res 48:9969-9985 (2020). [Pubmed]

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