DNA Binding Motif
| Accessions: | MEIS3_DBD_1 (HumanTF 1.0), MA0775.1 (JASPAR 2024) |
| Names: | MEIS3 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, JASPAR 2024 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | Site type: monomeric; SELEX cycle: 2, HT-SELEX |
| Length: | 8 |
| Consensus: | wTGACAgs |
| Weblogo: |  |
| PSSM: | P0 A C G T 01 1866 60 1788 3451 w 02 465 383 260 7165 T 03 0 6 7165 0 G 04 7165 20 455 53 A 05 53 7165 8 160 C 06 7165 8 468 145 A 07 1690 1889 7165 2094 g 08 960 2342 2888 975 s |
| Type: | Heterodimer |
| Binding TFs: | MEIS3_DBD (Homeobox domain, Homeobox KN domain) Q99687 (Homeobox domain, Homeobox KN domain) Q99687 |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Knoepfler P. S., Calvo K. R., Chen H., Antonarakis S. E., Kamps M. P. Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc. Natl. Acad. Sci. USA 94:14553-14558 (1997). [Pubmed] |
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