DNA Binding Motif

Accessions: 3d1n_IK (3D-footprint 20231221)
Names: POU domain, class 6, transcription factor 1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Structure of human Brn-5 transcription factor in complex with corticotrophin-releasing hormone gene promoter
Length: 22
Consensus: ATATnnTATAnnyATAntTTAT
Weblogo:
PSSM: P0 A C G T
01 90 1 1 4 A
02 0 1 0 95 T
03 84 8 1 3 A
04 21 1 5 69 T
05 24 24 24 24 n
06 24 24 24 24 n
07 19 1 0 76 T
08 96 0 0 0 A
09 0 0 0 96 T
10 86 3 3 4 A
11 24 24 24 24 n
12 24 24 24 24 n
13 1 64 1 30 y
14 94 0 1 1 A
15 0 0 0 96 T
16 84 1 0 11 A
17 24 24 24 24 n
18 11 11 9 65 t
19 0 0 0 96 T
20 4 0 0 92 T
21 92 0 1 3 A
22 3 1 4 88 T
Binding TFs: 3d1n_I / 3d1n_K (Homeobox domain, Pou domain - N-terminal to homeobox domain)
Binding Sites: 3d1n_C
3d1n_D
Publications: Pereira J.H, Kim S.H. Structure of human Brn-5 transcription factor in complex with CRH gene promoter. Journal of structural biology 167:159-65 (2009). [Pubmed]

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