DNA Binding Motif

Accessions: 3gut_EGH (3D-footprint 20231221)
Names: Transcription factor p65
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of a higher-order complex of p50:RelA bound to the HIV-1 LTR
Length: 19
Consensus: TTCCgnnnGGGACnTTCCa
Weblogo:
PSSM: P0 A C G T
01 0 0 0 96 T
02 0 0 0 96 T
03 0 96 0 0 C
04 0 96 0 0 C
05 13 13 57 13 g
06 24 24 24 24 n
07 24 24 24 24 n
08 24 24 24 24 n
09 0 0 96 0 G
10 0 0 96 0 G
11 0 0 96 0 G
12 96 0 0 0 A
13 0 96 0 0 C
14 24 24 24 24 n
15 0 0 0 96 T
16 0 0 0 96 T
17 0 96 0 0 C
18 0 96 0 0 C
19 54 13 13 16 a
Type: Heterodimer
Binding TFs: 3gut_E / 3gut_G (Rel homology domain (RHD))
3gut_H (Rel homology domain (RHD))
Binding Sites: 3gut_I
3gut_J / 3gut_Y
Publications: Stroud J.C, Oltman A, Han A, Bates D.L, Chen L. Structural basis of HIV-1 activation by NF-kappaB--a higher-order complex of p50:RelA bound to the HIV-1 LTR. Journal of molecular biology 393:98-112 (2009). [Pubmed]

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