DNA Binding Motif

Accessions: 2r5z_AB (3D-footprint 20231221)
Names: Homeotic protein Sex combs reduced
Organisms: Drosophila melanogaster
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Structure of Scr/Exd complex bound to a DNA sequence derived from the fkh gene
Length: 11
Consensus: AGATTAATcGG
Weblogo:
PSSM: P0 A C G T
01 66 10 10 10 A
02 0 0 96 0 G
03 96 0 0 0 A
04 0 0 0 96 T
05 0 0 0 96 T
06 96 0 0 0 A
07 96 0 0 0 A
08 10 10 10 66 T
09 10 60 10 16 c
10 5 5 80 6 G
11 5 1 85 5 G
Type: Heterodimer
Binding TFs: 2r5z_B (Homeobox domain, Homeobox KN domain)
2r5z_A (Homeobox domain)
Binding Sites: 2r5z_C
2r5z_D
Publications: Joshi R, Passner J.M, Rohs R, Jain R, Sosinsky A, Crickmore M.A, Jacob V, Aggarwal A.K, Honig B, Mann R.S. Functional specificity of a Hox protein mediated by the recognition of minor groove structure. Cell 131:530-43 (2007). [Pubmed]

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