DNA Binding Motif

Accessions: 1apl_CD (3D-footprint 20231221)
Names: PROTEIN (MAT-ALPHA2 HOMEODOMAIN)
Organisms: Saccharomyces cerevisiae, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: CRYSTAL STRUCTURE OF A MAT-ALPHA2 HOMEODOMAIN-OPERATOR COMPLEX SUGGESTS A GENERAL MODEL FOR HOMEODOMAIN-DNA INTERACTIONS
Length: 16
Consensus: TTGTAnTTnATnTACA
Weblogo:
PSSM: P0 A C G T
01 3 3 3 87 T
02 0 0 0 96 T
03 0 0 96 0 G
04 0 0 0 96 T
05 69 12 6 9 A
06 24 24 24 24 n
07 3 3 3 87 T
08 3 3 3 87 T
09 24 24 24 24 n
10 78 3 12 3 A
11 12 3 6 75 T
12 24 24 24 24 n
13 3 3 3 87 T
14 96 0 0 0 A
15 0 96 0 0 C
16 87 3 3 3 A
Type: Heterodimer
Binding TFs: 1apl_C (Homeobox domain, Homeobox KN domain)
1apl_D (Homeobox domain, Homeobox KN domain)
Binding Sites: 1apl_A
1apl_B
Publications: Wolberger C., Vershon A. K., Liu B., Johnson A. D., Pabo C. O. Crystal structure of a MATalpha2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions. Cell 67:517-528 (1991). [Pubmed]

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