DNA Binding Motif

Accessions: 2ayb_AB (3D-footprint 20231221)
Names: Regulatory protein E2
Organisms: Human papillomavirus type 6a
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of HPV6a E2 DNA Binding Domain bound to a 16 base pair DNA target
Length: 16
Consensus: CAACCGnnnnCGGTTG
Weblogo:
PSSM: P0 A C G T
01 5 81 5 5 C
02 96 0 0 0 A
03 80 5 6 5 A
04 0 96 0 0 C
05 0 96 0 0 C
06 5 6 80 5 G
07 24 24 24 24 n
08 24 24 24 24 n
09 24 24 24 24 n
10 24 24 24 24 n
11 5 80 5 6 C
12 0 0 96 0 G
13 0 0 96 0 G
14 5 5 5 81 T
15 0 0 0 96 T
16 5 5 81 5 G
Binding TFs: 2ayb_A / 2ayb_B (E2 (early) protein, C terminal)
Binding Sites: 2ayb_C / 2ayb_D
Publications: Hooley E, Fairweather V, Clarke A.R, Gaston K, Brady R.L. The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein. Nucleic acids research 34:3897-908 (2006). [Pubmed]

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