DNA Binding Motif

Accessions: MA0002.1 (JASPAR 2024)
Names: RUNX1
Organisms: Homo sapiens, Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: SELEX
Length: 11
Consensus: wwyTGyGGTww
Weblogo:
PSSM: P0 A C G T
01 10 2 3 11 w
02 12 2 1 11 w
03 4 7 1 14 y
04 1 1 0 24 T
05 2 0 23 1 G
06 2 8 0 16 y
07 0 0 26 0 G
08 0 0 26 0 G
09 0 1 0 25 T
10 8 2 0 16 w
11 13 2 4 7 w
Type: Heterodimer
Binding TFs: Q01196 (Runt domain, Runx inhibition domain)
Q01196
Binding Sites: MA0002.1.1
MA0002.1.10
MA0002.1.11
MA0002.1.12
MA0002.1.13
MA0002.1.14
MA0002.1.15
MA0002.1.16
MA0002.1.17
MA0002.1.18
MA0002.1.19
MA0002.1.2
MA0002.1.20
MA0002.1.3
MA0002.1.4
MA0002.1.5
MA0002.1.6
MA0002.1.7
MA0002.1.8
MA0002.1.9
Publications: Meyers S., Downing J. R., Hiebert S. W. Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins:the runt homology domain is required for DNA binding and protein-protein interactions. Mol. Cell. Biol. 13:6336-6345 (1993). [Pubmed]

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