DNA Binding Motif

						

			
Accessions: POU5F1P1_DBD_1 (HumanTF 1.0), MA0792.1 (JASPAR 2024)

			
Names: POU5F1P1, POU5F1B
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 2, HT-SELEX
Length: 9
Consensus: TATGywAAT
Weblogo: 
PSSM: P0      A      C      G      T
01   1326   1778    808   9519      T
02   9519     21     67     84      A
03    171    364    206   9519      T
04    322     94   9519   1790      G
05    398   9519   1293   3828      y
06   6299     51     65   3220      w
07   9519    144    856    896      A
08   9519     65     97    203      A
09   1559    537    750   9519      T
Type: Heterodimer
Binding TFs: POU5F1P1_DBD (Homeobox domain, Pou domain - N-terminal to homeobox domain)
Q06416 (Homeobox domain, Pou domain - N-terminal to homeobox domain)
Q06416
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Ingraham H. A., Flynn S. E., Voss J. W., Albert V. R., Kapiloff M. S., Wilson L., Rosenfeld M. G. The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions. Cell 61:1021-1033 (1990). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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