DNA Binding Motif

Accessions: 6vw0_CDFJM (3D-footprint 20231221)
Names: RNA polymerase sigma factor SigA
Organisms: Mycobacterium tuberculosis, strain ATCC 25618 / H37Rv
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Mycobacterium tuberculosis RNAP S456L mutant open promoter complex
Length: 39
Consensus: CTTGACtnnnnnnnnnnnnnTnTnTTAGACTGGCnngGT
Weblogo:
PSSM: P0 A C G T
01 0 96 0 0 C
02 0 0 0 96 T
03 0 0 0 96 T
04 0 0 96 0 G
05 96 0 0 0 A
06 0 96 0 0 C
07 21 21 10 44 t
08 24 24 24 24 n
09 24 24 24 24 n
10 24 24 24 24 n
11 24 24 24 24 n
12 24 24 24 24 n
13 24 24 24 24 n
14 24 24 24 24 n
15 24 24 24 24 n
16 24 24 24 24 n
17 24 24 24 24 n
18 24 24 24 24 n
19 24 24 24 24 n
20 24 24 24 24 n
21 0 0 0 96 T
22 24 24 24 24 n
23 0 0 0 96 T
24 24 24 24 24 n
25 0 0 0 96 T
26 0 0 0 96 T
27 96 0 0 0 A
28 0 0 96 0 G
29 96 0 0 0 A
30 0 96 0 0 C
31 0 0 0 96 T
32 0 0 96 0 G
33 0 0 96 0 G
34 0 96 0 0 C
35 24 24 24 24 n
36 24 24 24 24 n
37 21 21 33 21 g
38 0 0 96 0 G
39 0 0 0 96 T
Type: Heterodimer
Binding TFs: 6vw0_F (Sigma-70 factor, region 1.2, Sigma-70 region 3, Sigma-70 region 2 , Sigma-70, region 4)
6vw0_M (CarD-like/TRCF domain)
Binding Sites: 6vw0_O
6vw0_P
Publications: Lilic M, Chen J, Boyaci H, Braffman N, Hubin EA, Herrmann J, Müller R, Mooney R, Landick R, Darst SA, Campbell EA. The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc Natl Acad Sci U S A 117:30423-30432 (2020). [Pubmed]

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