DNA Binding Motif

Accessions: IRF8_full (HumanTF 1.0), MA0652.1 (JASPAR 2024)
Names: IRF8
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4, HT-SELEX
Length: 14
Consensus: yCGAAACCGAAACT
Weblogo:
PSSM: P0 A C G T
01 1309 1996 571 2002 y
02 63 5878 19 884 C
03 3 0 5878 2 G
04 5878 2 0 0 A
05 5878 0 0 33 A
06 5878 0 0 3 A
07 54 5878 580 6 C
08 6 5878 0 1228 C
09 0 0 5878 0 G
10 5878 0 3 0 A
11 5878 0 2 68 A
12 5878 5 0 0 A
13 11 5878 1061 15 C
14 321 1454 8 5878 T
Type: Heterodimer
Binding TFs: IRF8_full (Interferon regulatory factor transcription factor, Interferon-regulatory factor 3)
Q02556 (Interferon regulatory factor transcription factor, Interferon-regulatory factor 3)
Q02556
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Marquis JF, Kapoustina O, Langlais D, Ruddy R, Dufour CR, Kim BH, MacMicking JD, Giguère V, Gros P. Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosis. PLoS Genet : (2011). [Pubmed]

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