DNA Binding Motif

						

			
Accessions: SOX21_DBD_1 (HumanTF 1.0), MA0866.1 (JASPAR 2024)

			
Names: SOX21
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4; Possible binding to single stranded DNA, HT-SELEX
Length: 15
Consensus: AACAATkkyAkTGTT
Weblogo: 
PSSM: P0      A      C      G      T
01  15806     83    199    106      A
02  15806    250   2008    232      A
03     15  15806     28     24      C
04  15806      7     22      1      A
05  15806     13     56      0      A
06      6      3     30  15806      T
07    348     15   9624   5819      k
08   1909   1271   7901   4725      k
09    128   7221     73   8384      y
10  15806     20     40      1      A
11     64      9  10733   5073      k
12     84     15     77  15806      T
13     10      4  15806      8      G
14     33     17     37  15806      T
15    279    790    484  15806      T
Type: Heterodimer
Binding TFs: Q9Y651 (HMG (high mobility group) box, Domain of unknown function (DUF1898), SOX transcription factor)
SOX21_DBD (HMG (high mobility group) box, Domain of unknown function (DUF1898))
Q9Y651
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Harley VR, Clarkson MJ, Argentaro A. The molecular action and regulation of the testis-determining factors, SRY (sex-determining region on the Y chromosome) and SOX9 [SRY-related high-mobility group (HMG) box 9]. Endocr Rev 24:466-87 (2003). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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