DNA Binding Motif

Accessions: 5yi2_EF (3D-footprint 20231221)
Names: Zinc transport transcriptional regulator
Organisms: Lactococcus lactis, Lactococcus lactis subsp. lactis (strain IL1403)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Structure of Lactococcus lactis ZitR, wild type in complex with DNA
Length: 12
Consensus: TtaACnAGTTAA
Weblogo:
PSSM: P0 A C G T
01 0 0 0 96 T
02 9 9 13 65 t
03 64 0 13 19 a
04 83 9 0 4 A
05 0 96 0 0 C
06 24 24 24 24 n
07 82 0 5 9 A
08 0 0 96 0 G
09 0 0 0 96 T
10 1 9 13 73 T
11 86 0 6 4 A
12 96 0 0 0 A
Type: Heterodimer
Binding TFs: 5yi2_E (Bacterial regulatory protein, arsR family, MarR family, Iron dependent repressor, N-terminal DNA binding domain, TFIIE alpha subunit, Transcriptional regulator, MarR family, Winged helix-turn-helix DNA-binding, Winged helix DNA-binding domain)
5yi2_F (Bacterial regulatory protein, arsR family, MarR family, Iron dependent repressor, N-terminal DNA binding domain, TFIIE alpha subunit, Transcriptional regulator, MarR family, Winged helix-turn-helix DNA-binding, Winged helix DNA-binding domain)
Binding Sites: 5yi2_G / 5yi2_H
Publications: Zhu R, Song Y, Liu H, Yang Y, Wang S, Yi C, Chen PR. Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation. Proc Natl Acad Sci U S A 114:13661-13666 (2017). [Pubmed]

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