DNA Binding Motif

Accessions: 5cbx_EF (3D-footprint 20210203)
Names: AncGR DNA Binding Domain
Organisms: Homo sapiens
Libraries: 3D-footprint 20210203 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: AncGR DNA Binding Domain - (+)GRE Complex
Length: 13
Consensus: GnrCAnnnTGtna
Weblogo:
PSSM: P0 A C G T
01 6 0 79 11 G
02 24 24 24 24 n
03 39 11 30 16 r
04 0 96 0 0 C
05 96 0 0 0 A
06 24 24 24 24 n
07 24 24 24 24 n
08 24 24 24 24 n
09 0 0 0 96 T
10 0 0 96 0 G
11 19 16 11 50 t
12 24 24 24 24 n
13 62 16 13 5 a
Type: Heterodimer
Binding TFs: 5cbx_F (Zinc finger, C4 type (two domains))
5cbx_E (Zinc finger, C4 type (two domains))
Binding Sites: 5cbx_H
5cbx_G
Publications: Hudson WH, Kossmann BR, de Vera IM, Chuo SW, Weikum ER, Eick GN, Thornton JW, Ivanov IN, Kojetin DJ, Ortlund EA. Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space. Proc Natl Acad Sci U S A 113:326-31 (2016). [Pubmed]

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