DNA Binding Motif

Accessions: 6pw2_ABCD (3D-footprint 20231221)
Names: Epstein-Barr nuclear antigen 1
Organisms: Epstein-Barr virus (strain B95-8) (HHV-4), Human herpesvirus 4
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Structural Basis for Cooperative Binding of EBNA1 to the Epstein-Barr Virus Dyad Symmetry Minimal Origin of Replication
Length: 36
Consensus: ATAGCnnnTnTTnCCCnnnGGGnAGmnnnnnCTATC
Weblogo:
PSSM: P0 A C G T
01 94 1 0 1 A
02 1 1 2 92 T
03 92 1 2 1 A
04 7 1 87 1 G
05 1 84 10 1 C
06 24 24 24 24 n
07 24 24 24 24 n
08 24 24 24 24 n
09 7 5 8 76 T
10 24 24 24 24 n
11 0 0 2 94 T
12 0 1 1 94 T
13 24 24 24 24 n
14 0 86 1 9 C
15 0 96 0 0 C
16 0 96 0 0 C
17 24 24 24 24 n
18 24 24 24 24 n
19 24 24 24 24 n
20 3 1 92 0 G
21 0 0 96 0 G
22 3 7 82 4 G
23 24 24 24 24 n
24 95 1 0 0 A
25 1 4 90 1 G
26 28 51 10 7 m
27 24 24 24 24 n
28 24 24 24 24 n
29 24 24 24 24 n
30 24 24 24 24 n
31 24 24 24 24 n
32 3 92 1 0 C
33 0 1 0 95 T
34 96 0 0 0 A
35 0 5 1 90 T
36 0 96 0 0 C
Binding TFs: 6pw2_A / 6pw2_B / 6pw2_C / 6pw2_D (Epstein Barr virus nuclear antigen-1, DNA-binding domain)
Binding Sites: 6pw2_E
6pw2_F
Publications: Malecka KA, Dheekollu J, Deakyne JS, Wiedmer A, Ramirez UD, Lieberman PM, Messick TE. Structural Basis for Cooperative Binding of EBNA1 to the Epstein-Barr Virus Dyad Symmetry Minimal Origin of Replication. J Virol : (2019). [Pubmed]

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