DNA Binding Motif

						

			
Accessions: ETV6_full_2 (HumanTF 1.0), MA0645.1 (JASPAR 2024)

			
Names: ETV6
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 3, HT-SELEX
Length: 10
Consensus: msCGGAAGTr
Weblogo: 
PSSM: P0      A      C      G      T
01   9414   6562   4684   2002      m
02    342   2394   4292    441      s
03   1476   6379    397    308      C
04      7      0   6687     13      G
05     21      0   6687     22      G
06   6687      0      7      0      A
07   6687     13     32     41      A
08    768     52   6687      0      G
09    184    834    233   6687      T
10   2049    342   3205   1091      r
Type: Heterodimer
Binding TFs: P41212 (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
ETV6_full (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
P41212
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Green SM, Coyne HJ 3rd, McIntosh LP, Graves BJ. DNA binding by the ETS protein TEL (ETV6) is regulated by autoinhibition and self-association. J Biol Chem 285:18496-504 (2010). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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