DNA Binding Motif

Accessions: ETV6_full_2 (HumanTF 1.0), MA0645.1 (JASPAR 2018)
Names: ETV6
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2018 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Khan A, Fornes O, Stigliani A, Gheorghe M, Castro-Mondragon JA, van der Lee R, Bessy A, Cheneby , Kulkarni SR, Tan G, Baranasic D, Arenillas DJ, Sandelin A, Vandepoele K, Lenhard B, Ballester B, Wasserman WW, Parcy F, Mathelier A (2017) JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework. Nucleic Acids Res. doi: 10.1093/nar/gkx1126 [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 3, HT-SELEX
Length: 10
Consensus: msCGGAAGTr
Weblogo:
PSSM: P0 A C G T
01 9414 6562 4684 2002 m
02 342 2394 4292 441 s
03 1476 6379 397 308 C
04 7 0 6687 13 G
05 21 0 6687 22 G
06 6687 0 7 0 A
07 6687 13 32 41 A
08 768 52 6687 0 G
09 184 834 233 6687 T
10 2049 342 3205 1091 r
Type: Heterodimer
Binding TFs: P41212 (Sterile alpha motif (SAM)/Pointed domain, Ets-domain)
ETV6_full (Sterile alpha motif (SAM)/Pointed domain, Ets-domain)
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Green SM, Coyne HJ 3rd, McIntosh LP, Graves BJ. DNA binding by the ETS protein TEL (ETV6) is regulated by autoinhibition and self-association. J Biol Chem 285:18496-504 (2010). [Pubmed]

Disclaimer

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research.