DNA Binding Motif

						

			
Accessions: 6pax_A (3D-footprint 20231221)

			
Names: HOMEOBOX PROTEIN PAX-6
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: CRYSTAL STRUCTURE OF THE HUMAN PAX-6 PAIRED DOMAIN-DNA COMPLEX REVEALS A GENERAL MODEL FOR PAX PROTEIN-DNA INTERACTIONS
Length: 12
Consensus: ACGcAnnCGTGC
Weblogo: 
PSSM: P0      A      C      G      T
01     96      0      0      0      A
02      2     92      2      0      C
03      0      0     96      0      G
04      2     62     13     19      c
05     67      2     19      8      A
06     24     24     24     24      n
07     24     24     24     24      n
08     16     73      2      5      C
09      2      2     92      0      G
10      5      2      2     87      T
11      0      4     90      2      G
12      5     70      2     19      C
Binding TFs: 6pax_A ('Paired box' domain)
Binding Sites: 6pax_B
6pax_C
			
Publications: Xu H.E, Rould M.A, Xu W, Epstein J.A, Maas R.L, Pabo C.O. Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding. Genes & development 13:1263-75 (1999). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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