DNA Binding Motif

						

			
Accessions: CLOCK_EVX1_2_3 (HumanTF2 1.0)

			
Names: CLOCK_EVX1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 18
Consensus: trATwAtyrmcrMACGTG
Weblogo: 
PSSM: P0      A      C      G      T
01     91    213    132    612      t
02    612    211    314     59      r
03    612      9      2     31      A
04     19      9     46    612      T
05    476    307    132    612      w
06    612     12     19     25      A
07     92     25    105    390      t
08     52    213     75    272      y
09    230     37    269     76      r
10    259    223     59     70      m
11    120    324    142     26      c
12    245    100    210     56      r
13    240    612     31      0      M
14    612     29     76     59      A
15      3    612      5    174      C
16     33      7    612      2      G
17      0     68     16    612      T
18      0      0    612     34      G
Type: Heterodimer
Binding TFs: CLOCK_TF1 / CLOCK_TF2 (Helix-loop-helix DNA-binding domain)
EVX1_TF1 / EVX1_TF2 (Homeobox domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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