DNA Binding Motif

						

			
Accessions: HEY1_DBD (HumanTF 1.0), MA0823.1 (JASPAR 2024)

			
Names: HEY1
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 3, HT-SELEX
Length: 10
Consensus: grCACGTGyc
Weblogo: 
PSSM: P0      A      C      G      T
01    437    761   1788    352      g
02   1373    656   1199    110      r
03      1   3338      3     15      C
04   3338     30    123     21      A
05      0   3338      0      0      C
06      0     18   3338      0      G
07      0    474     10   3338      T
08     32     19   3338     22      G
09    333   1762    380    863      y
10    475   2172    373    318      c
Type: Heterodimer
Binding TFs: HEY1_DBD (Helix-loop-helix DNA-binding domain, Hairy Orange)
Q9Y5J3 (Helix-loop-helix DNA-binding domain, Hairy Orange)
Q9Y5J3
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Heisig J, Weber D, Englberger E, Winkler A, Kneitz S, Sung WK, Wolf E, Eilers M, Wei CL, Gessler M. Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors. PLoS Genet : (2012;8(5):e1002728.). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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