DNA Binding Motif

						

			
Accessions: SMAD3_DBD (HumanTF 1.0), MA0795.1 (JASPAR 2024)

			
Names: SMAD3
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 3, HT-SELEX
Length: 10
Consensus: yGTCTAGACA
Weblogo: 
PSSM: P0      A      C      G      T
01    554   1829     87   1662      y
02     20     16   3491     18      G
03    103     29     83   3491      T
04      9   3491     11      6      C
05      0     46     31   3491      T
06   3491     30     22      0      A
07      0     10   3491      3      G
08   3491    199      5     56      A
09     20   3491     10     20      C
10   3491    434    316    758      A
Type: Heterodimer
Binding TFs: P84022 (MH1 domain, MH2 domain, Interferon-regulatory factor 3)
SMAD3_DBD (MH1 domain)
P84022
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Chen S, Kulik M, Lechleider RJ. Smad proteins regulate transcriptional induction of the SM22alpha gene by TGF-beta. Nucleic Acids Res 31:1302-10 (2003). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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