DNA Binding Motif

Accessions: 1hjb_DEF (3D-footprint 20231221)
Names: CCAAT/ENHANCER BINDING PROTEIN BETA
Organisms: Homo sapiens, Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: CRYSTAL STRUCTURE OF RUNX-1/AML1/CBFALPHA RUNT DOMAIN AND C/EBPBETA BZIP HOMODIMER BOUND TO A DNA FRAGMENT FROM THE CSF-1R PROMOTER
Length: 18
Consensus: AACCACAnnnTTTGGAAA
Weblogo:
PSSM: P0 A C G T
01 86 3 4 3 A
02 87 3 3 3 A
03 0 96 0 0 C
04 0 96 0 0 C
05 86 3 4 3 A
06 0 96 0 0 C
07 86 3 3 4 A
08 24 24 24 24 n
09 24 24 24 24 n
10 24 24 24 24 n
11 0 0 0 96 T
12 0 10 3 83 T
13 3 3 3 87 T
14 3 4 86 3 G
15 0 0 96 0 G
16 81 9 3 3 A
17 80 9 3 4 A
18 96 0 0 0 A
Type: Heterodimer
Binding TFs: 1hjb_F (Runt domain)
1hjb_D / 1hjb_E (bZIP transcription factor, Basic region leucine zipper)
Binding Sites: 1hjb_I
1hjb_J
Publications: Tahirov T.H, Inoue-Bungo T, Morii H, Fujikawa A, Sasaki M, Kimura K, Shiina M, Sato K, Kumasaka T, Yamamoto M, Ishii S, Ogata K. Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta. Cell 104:755-67 (2001). [Pubmed]

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