DNA Binding Motif

Accessions: 5jvt_AD (3D-footprint 20231221)
Names: Friend leukemia integration 1 transcription factor
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of the DNA binding domain of transcription factor FLI1 in complex with an 11-mer DNA GACCGGAAGTG
Length: 16
Consensus: TTCCGnnGgnnCGGAa
Weblogo:
PSSM: P0 A C G T
01 11 5 11 69 T
02 0 0 0 96 T
03 0 96 0 0 C
04 0 96 0 0 C
05 0 0 96 0 G
06 24 24 24 24 n
07 24 24 24 24 n
08 5 16 70 5 G
09 13 16 56 11 g
10 24 24 24 24 n
11 24 24 24 24 n
12 0 96 0 0 C
13 0 0 96 0 G
14 0 0 96 0 G
15 96 0 0 0 A
16 63 11 11 11 a
Type: Heterodimer
Binding TFs: 5jvt_D (Ets-domain)
5jvt_A (Ets-domain)
Binding Sites: 5jvt_B / 5jvt_E
5jvt_C / 5jvt_F
Publications: Hou C, Weidenbach S, Cano KE, Wang Z, Mitra P, Ivanov DN, Rohr J, Tsodikov OV. Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1. Nucleic Acids Res 44:8990-9004 (2016). [Pubmed]

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